The net effect of metabolic acidosis is a state of disrepair and degeneration. Metabolic acidosis, oxidative stress makers, and repair deficit inflammation are the antecedents of autoimmune and immune dysfunction which functionally and metabolically overlap with debilitating chronic conditions that affect or are affected by thyroid, adrenals, or reproductive glands. Restoring alkaline balance is health promoting and restorative. The goal of this approach is to reverse intracellular acidosis, which impairs electron transport, reduces energy production, and impedes detoxification.